Your body doesn't make B12 on its own, you get it from animal foods (meat, fish, eggs, dairy) or from supplementation
You could be unintentionally blunting your results or worsening your side effects without even realizing it
For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair
[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone
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The treatment also has important therapeutic benefits