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Lilly's oral GLP-1, orforglipron, is successful in third Phase 3 trial, triggering global regulatory submissions [press release]

It affects 1923% of adults at higher doses in clinical trials, peaking during dose-escalation weeks, and runs roughly 23 times higher than placebo across every dose group

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This double-blind, placebo-controlled study randomized adults with a BMI 30 or 27 plus at least one obesity-related comorbidity (excluding diabetes) who had achieved 5% weight loss after 12 weeks of lifestyle modification to receive tirzepatide or placebo weekly for 72 weeks

Bariatric surgery is less scalable than GLP-1 medications, and people with obesity who have access to bariatric surgery are likely to choose GLP-1 medications