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Accumulation of misfolded proteins in the ER triggers the unfolded protein response (UPR), in which C/EBP homologous protein (CHOP) is activated, subsequently activating the caspase family and inducing chondrocyte death 12

Furthermore, detection was carried out at 214 nm, strategically chosen as the UV detection wavelengths for potassium dihydrogen phosphate and triethylamine are mostly below 260 nm