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By correcting for possible imbalances, we aimed at reducing infection-related gastric pathologies

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11.5 Pharmacokinetics and bioavailability It is evident that following oral administration, resveratrol is rapidly absorbed in the gastrointestinal tract (75%) with an extensive first-pass metabolism in the intestine and liver, lowering its oral bioavailability (ranging from 2.6 to 75% in humans and 2029% in rats fed 50 mg/kg) [198]

J Neurosci Res 102(1):e25281 Lee SH, Kim HS, An YS, Chang J, Choi J, Im GJ (2015) Protective effect of resveratrol against cisplatin-induced ototoxicity in HEI-OC1 auditory cells

Keep the goal small, not extreme

Need for Precursors Some children benefit more from NAC, vitamin B12, or folate, which support glutathione production