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Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig
Diabetic Medicine, 28 (8), 972975
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This makes it especially useful in early to moderate stages of hair loss, when follicles are still present but inactive
These data suggested that the binding of CCW16 caused inhibition of PRDX activity resulting in oxidative stress which was also supported by the observed upregulation of HMOX1 upon treatment of cells with CCW16 or CCW16-based PROTACs ( Figure 2D )
