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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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Individuals with MTHFR polymorphisms or baseline methylation impairments may want to monitor homocysteine levels if using 5-Amino-1MQ beyond 12 weeks