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PLoS ONE 11 , e0154022 (2017)
El ensayo OASIS 1, en personas con obesidad y sobrepeso sin DM2, evidenci que la SEMA oral a 50 mg logr una prdida media del 15,1% del peso corporal frente al 2,4% con placebo en 68 semanas, aunque con una incidencia relevante de efectos gastrointestinales y disestesias en el 13% de participantes, lo que ha impulsado el estudio de dosis intermedias para optimizar eficacia y tolerabilidad
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Trials indicate it could assist adults battling obesity or type 2 diabetes
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