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It is possible that xanthine oxidase inhibitors unveil a granulomatous diathesis in certain patients and hyperuricemia is the common feature connecting our case with the previous allopurinol-induced interstitial granulomatous reactions

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The outcome suggested that a transient and limited increase in gut permeability compared with the unregulated breach of the gut barrier function due to the TJ deregulation and epithelial cell apoptosis can rather lead to a dominant regulatory immune response to gut microbiota antigens and to a net anti-inflammatory effect

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