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Contact your GP or prescribing clinician if you experience: Persistent or worsening fatigue that interferes with daily activities and does not improve with adequate rest Significant breathlessness during normal activities or at rest Chest pain or palpitations these require same-day assessment Severe or persistent dizziness , particularly if associated with fainting episodes Marked pallor noticed by yourself or others Unusual food cravings (pica) or restless legs syndrome Difficulty concentrating or cognitive changes affecting work or daily function Heavy menstrual bleeding or any unexplained bleeding Signs of gastrointestinal bleeding black or tarry stools, persistent change in bowel habit, unintentional weight loss beyond expected with Wegovy, or difficulty swallowing Seek urgent medical attention (call 999 or attend A&E) if you develop: Severe chest pain or pressure Sudden severe breathlessness Loss of consciousness or near-fainting Rapid heart rate with chest discomfort These symptoms may indicate severe anaemia or other serious conditions requiring immediate assessment

Interactions of G proteins with these receptor domains contribute to the separation of the G protein RHD and AHD, disruption of the P loop and the nucleotide-binding pocket, all of which contribute to the release of GDP, one of the key rate-limiting steps in G protein activation 36