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Val-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid peptide in rats

From a more general point of view, it is particularly interesting that these drugs exert their therapeutic action by acting on the brain to reduce appetite and thus create a significant caloric deficit

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Cleveland Clinic explains that muscle tissue is metabolically active, meaning it requires more energy to maintain than fat tissue. When muscle mass decreases, resting energy expenditure may also decrease. Harvard Health Publishing explains that muscle tissue influences resting metabolic rate, meaning it affects how many calories your body uses at rest. Mayo Clinic explains that strength training helps maintain and build muscle, improve balance, and support everyday physical tasks. The American Cancer Society notes that strength training supports daily function, mobility, and overall physical health. The takeaway is simple: pair weight loss with resistance training so your body keeps getting a clear signal to use and maintain muscle

The key pathological hallmarks of AD include amyloid-beta (A) plaque accumulation, neurofibrillary tangles of hyperphosphorylated tau, chronic neuroinflammation, oxidative stress, and mitochondrial dysfunction (Lv et al., 2020)