The relevant published cosmetic studies showing human skin improvement (such as the split-face studies cited in Leyden and colleagues' review of copper peptides in cosmetics) used concentrations in the low parts-per-million range, meaning micrograms per milliliter
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It is supplied here strictly as a reference material for in-vitro and laboratory investigation
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These results were achieved by 36 months, though significant improvements were observed by 6 months (Reich 2016)
LIPO-010 (Phase III, n=412) Falutz et al