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This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

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Secondary endpoints included changes in total alcohol consumption, number of days without alcohol, number of drinks per drinking day, and craving, among others (these included various metabolic measures and biomarkers)

DOI : 10.1080/07853890.2019.1659511

The body positive movement of the 2010s-2020s has been, largely, a failure, with the pendulum now resolutely swinging in the other direction