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The mechanisms of action underpinning the CV and renal protection seen with SGLT2 inhibitors remain uncertain

All are GLP-1 agonists

Vitamin A Toxicity Is Real Because isotretinoin is itself a vitamin A derivative, the body treats any additional vitamin A intake as a surplus

doi: 10.1038/s41581-020-0256-y 12 YuanJOfengeimD

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Another study used a genetic loss of function mouse model to delete the GLP-1R in vagal afferent/effect nerves ( Phox2b-Cre Glp1r flox/flox ) (Sisley et al., 2014)