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This appetite suppression is the primary mechanism driving weight loss results

doi.org/10.1016/j.bcp. 10

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5 Exercise as a modulator of musclevasculature interactions 5.1 Exercise-induced signaling pathways improving endothelial and muscle function Exercise constitutes a robust, pleiotropic stimulus that orchestrates adaptive responses in both skeletal muscle and the vascular endothelium, thereby facilitating the restoration and preservation of the musclevasculature axis, which tends to deteriorate with advancing age

These plateaus are physiological adaptations and do not indicate treatment failure