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This is currently being investigated in a phase 2 clinical trial (127)

Consider working with a trainer or following a structured program designed for people in caloric deficit

Whether similar mechanisms pertain to cannabis is unclear since there are no studies that have evaluated the effects of GLP1 signaling in the aversive or rewarding effects of THC

This approach prevents treatment interruptions but requires accurate dose predictions and consistent therapy commitment

Nature 590, 140145

Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of semaglutide-treated patients versus 0.4% of placebo-treated patients during clinical trials of the semaglutide injection for weight management