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The pituitary responds to secretagogue stimulation within the bounds of its natural feedback mechanisms

Pain fibers are in the skin, and going through the skin too slowly or too forcefully may increase the pain

This allows assessment of tolerance before increasing

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Geographically, the evidence is heavily concentrated in China and other East Asian countries, with minimal data from Western populations, which limits generalizability across ethnicities, healthcare systems, and regulatory contexts

Detailed clinicopathological characteristics were presented in Table 5