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GABA modulation: In alcohol-naive rats, semaglutide increases the release of gamma-aminobutyric acid (GABA), a neurotransmitter that promotes calmness and reduces anxiety

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Moreover, efpeglenatide therapy reduced the risk of CV disease by about 27% compared to the placebo in the Effect of Efpeglenatide on Cardiovascular Outcomes (AMPLITUDE-O) study [51]

Malonyl-CoA, the product of acetyl-CoA carboxylases (ACC), inhibits CPT1A

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