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Whole foods like fruits, vegetables, lean proteins, and whole grains provide essential nutrients that complement semaglutide's effects, helping to promote satiety and regulate blood sugar
The yo-yo effect only occurs when a person reverts to old, unhealthy overeating patterns
It also supports the ammonia recycling process and the metabolism of nitric oxide
The head-to-head SURMOUNT-5 trial, published in the New England Journal of Medicine in 2025, found tirzepatide produced about 20% body weight loss versus about 14% for semaglutide over 72 weeks
In writing about her own experience in using the medicine to help her shed 40 pounds, Washington Post columnist Ruth Marcus in June noted that Novo Nordisk mentioned the potential for weight loss in its ubiquitous cable ads (Oh-oh-oh, Ozempic!) The American Society of Health-System Pharmacists has reported shortages of semaglutide due to demand, leaving some people with diabetes struggling to find supply of the medicine
Fujioka T, Sakamoto Y, Mimura G
