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A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet

Potanin SS, Morozova MA

The local GI argument is the strongest case for capsules, but it is rarely explained correctly If BPC-157 is degraded locally in the gut lumen and acts on GI epithelial receptors before degradation, then high oral bioavailability is not required for a GI-local effect

Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk