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MSCs with high GSH levels have improved hyaline cartilage regeneration in vivo To confirm that the highly functional stem cells isolated using FreSHtracer had regenerative effects on cartilage defects in vivo, we generated a 4-mm-diameter chondral defect in the trochlear groove of rabbits and compared the cartilage regenerative efficacy of GSH-high and GSH-low hES-MSCs

For the paraffin block preparation, the samples were submerged in paraffin at 60 C and incubated overnight

Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells

10.1038/s41586-019-1707-0 78

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To address this, Parkin et al