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Semaglutide currently has the strongest clinical evidence base for alcohol-related applications
Effectiveness : Bariatric surgery can result in 2030% weight loss, while Semaglutide averages 15%a comparable outcome without surgery
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70 For example, compound 2j, a triazole-containing derivative, has demonstrated high potency and comparable efficacy to danuglipron in preclinical studies, suggesting it could serve as a lead compound for further development
The phase 2a liver-specific trial showed: 1 mg dose: 42.9% reduction in liver fat 4 mg dose: 57.0% reduction in liver fat 8 mg dose: 81.4% reduction in liver fat 12 mg dose: 82.4% reduction in liver fat An 82% reduction in liver fat is extraordinary
The result should be treated as an estimate rather than a fixed target
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