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Several key sequence features underpin the triple receptor agonist activity of the molecule: Position 1 (Histidine) : The N-terminal histidine residue is critically important for glucagon receptor activation

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NaBPC157 (10 g or 10 ng/kg b.w., i.p.) or saline (5.0 ml/kg b.w., i.p.) was applied either 1 hour before or 1 hour after both carotid arteries were ligated for 3 or 6 hours in rats

3a), whereas its upregulation made cells more resistant (Fig

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