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Description

Two N/P ratios (positively charged amine groups of the carrier (N) of the dendrimer / negatively charged phosphorus (P) of siRNA) were tested: 1:1.5 (20.8 nM PURE G4 -LA 12 , 29.6 nM siRNA) and 1:2 (20.8 nM PURE G4 -LA 12 , 39.4 nM siRNA), and the dendriplexes formation was confirmed on a 2% (w/v) agarose gel electrophoresis

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While BPC-157 itself demonstrates gastric stability, the enteric coating provides an additional layer of protection and ensures consistent release in the intestinal lumen, where the majority of peptide absorption occurs

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