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Topical formulations (typically 0.1% to 2% concentration creams or serums) are applied directly to target tissue areas such as skin, scars, or joints
The two strategies are therefore not substitutes, and they have very different evidence profiles
Administration methods include intramuscular (IM) and intravenous (IV) injections
CL/F and V z /F showed no consistent pattern across groups
the current spatial resolution does not allow differentiation of GSH levels among specific nuclei such as the VPM, VPL, or pulvinar, and future studies with higher spatial resolution or multi-voxel approaches may help delineate nucleus-specific GSH alterations
Document daily dose and site rotation to maintain consistency
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