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Hypoxia and inflammation activate p53 via phosphorylation
Bruin JE, Saber N, Braun N, et al
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At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)