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Further studies in pigs revealed that a high degree of NH2-terminal degradation of GLP-1 occured in the hepatic portal system (34), concomitant with the evidence that DPP-4 is found in high concentrations in hepatocytes and endothelial cells (35, 36)

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Hyperglycaemia during systemic GCs therapy occurs in the majority of hospitalised patients

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Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T