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Topiramate may also cause birth defects (particularly there is a risk of cleft lip and/or palate and low birth weight)

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Topline data from the Phase 3, open-label EMBER-3 clinical trial among patients with estrogen receptor 1 (ESR1) gene mutations who received prior endocrine therapy revealed a median progression-free survival (PFS) of 5.5 months with imlunestrant compared to 3.8 months with placebo (hazard ratio [HR], 0.62

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Rotating sites each week, choosing healthy skin, and using correct technique reduce the frequency of local reactions