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They remain relevant as inexpensive oral alternatives for patients refusing injection or with incretin contraindications

H2 blockers provide somewhat weaker acid suppression than PPIs with potentially fewer long-term concerns

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This allows oral megadoses (e.g., 1,000 g or more daily) to raise serum B levels even in individuals with pernicious anemia or low stomach acid

They may reduce the risk of heart disease, strokes, and kidney problems

By activating these receptor systems, researchers can investigate mechanisms involved in satiety signaling and metabolic regulation