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It was originally derived from a naturally occurring protein fragment identified in gastric tissue
Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
S.SeiwerthS.RogicD.KusecV.et al (2004)
Ongoing challenges to trial conduct include the substances short half-life, the availability of unregulated commercial products, and ensuring protocol compliance
It supports tissue repair, reduces inflammation, improves joint and muscle recovery, and enhances overall resilience
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