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Key Innovation: The addition of a C18 fatty diacid side chain extends its half-life to approximately 7 days, enabling once-weekly dosing similar to modern GLP-1 receptor agonists

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[107] Anti-seizure medications phenobarbital, pregabalin, primidone and topiramate are associated with lower than normal serum vitamin concentration

First-time prescribing of ADM tirzepatide also decreased (-7.9%), as did first-time prescribing of AOM tirzepatide (-9.5%) as well