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In monotherapy clinical trials of topiramate 50 to 200 mg/day for the prophylaxis of migraines, the following CNS effects occurred more frequently with topiramate than placebo: paresthesias (35% to 51% vs

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39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections

Both sound beneficial until you consider they operate in every tissue

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