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Obesity, a global health crisis driven by complex interplays of behaviour, environment and genetics, has reached pandemic proportions, demanding effective therapeutic interventions

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Nonetheless, recent observations have suggested that the lipid-lowering effect of nicotinic acid was not due to its anti-lipolytic activity (22)

GSK3, a serine-threonine kinase prominently expressed in the brain, augments the activity of -secretase while concurrently diminishing the activity of -secretases, thereby amplifying intra- and extracellular levels of A [59, 60]