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The hook

Pain or Tenderness: Pain often starts in the calf, feeling like cramping or soreness, and may extend to the foot or thigh

Watanabe Y, Fujita M, Ito Y, Okada T, Kusuoka H, Nishimura T

However, there are some studies that they're not in human studies these are in a dish, in vitro, or in a rodent, showing that looking at what GLP-1 does to breast cancer cells

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Besides the action of the GLP-1R agonist (GLP-1RA) on the brainadipocyte axis, there is also recent evidence that its direct action (independent of its CNS actions) in the white adipose tissue induces browning and enhances the lipolytic capacity and mitochondrial biogenesis [8]