david sinclair glutathione Dr Supplements for Longevity & Healthy Ageing Tips from Harvard's David Sinclair: – How much control do we

The standard GLOW protocol ratio is 5:1:1 for GHK-Cu:TB-500:BPC-157 by weight, reflecting GHK-Cus lower potency requiring higher doses to achieve comparable tissue effects

Tranexamic acid is the standout: research summarized in the National Library of Medicine describes topical tranexamic acid as "a promising treatment for melasma," working by interrupting the plasmin pathway that links UV exposure to melanocyte activation

This results in sustained release, better tissue targeting, stronger mitochondrial protection, and improved redox balance.

(2025, October 3)

In: StatPearls [Internet] 2020

If you use prescription tretinoin, the simplest structure is to alternate: apply tretinoin on its own nights and use GHK-Cu on the nights in between, so skin gets recovery support without a pH or tolerance clash