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Hypermutation in pathogenic bacteria

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Studies further indicate that in advanced I/R stages, AS-IV activates mitochondrial ATP-sensitive K + channels, leading to depolarization, reduced mitochondrial Ca 2+ uptake, and decreased mitochondrial calcium overload ( 4 Synergistic effects and mechanisms of AS-IV The therapeutic potential of AS-IV extends beyond its individual effects, particularly in its synergistic interactions with other natural compounds and commonly used pharmacological agents