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GLP-1 Results in Recent Studies In a 68-week study of almost 2000 patients, those taking GLP-1s for weight loss lost: 6% total body weight at 3 months 11% total body at 6 months 15% total body weight at 12 months What is GLP-1

These drugs also influence macrophage activation, thereby shifting the immune response from a pro-inflammatory (M1) state towards an anti-inflammatory (M2) state

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SRD5A1, a member of the steroid 5-reductase family (SRD5A1, SRD5A2, and SRD5A3) converting testosterone to dihydrotestosterone (DHT), was recently reported to be aberrantly expressed in several sex hormone-related cancers, such as breast cancer, endometrial cancer, and prostate cancer 4,5,6

The plan and settings matter

2 Methods 2.1 Protocol registration This study was implemented according to a priori-written protocol registered in PROSPERO (CRD42022337099, registered 13 June 2022) and the reporting was followed by the PRISMA ( Table S1 )