The reduced gene expression or deletion of MET in vivo in mice results in altered synapse maturation (reviewed in Ma and Qiu, 2019)
Losing weight helps reverse many of these changes
"As an analogy, in most cases, when I put someone on a blood pressure medication for hypertension and it lowers their blood pressure, I expect that when I take them off them the medication that their blood pressure will go back up." Jay says most of her patients don't love the idea of staying on the medications indefinitely
It felt like they really understood that weight loss is already challenging enough, so why make getting help any harder
Zepbound, for example, is designed for people with overweight (which is considered as a BMI of 27 or above) or obesity (a BMI of 30 or above) who also have one or more weight-related conditions like type 2 diabetes, high blood pressure, or high cholesterol
All other GLP-1s with FDA approval, such as Ozempic and Mounjaro, are approved for the treatment of type 2 diabetes