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In the landmark 72-week SURMOUNT-1 trial, participants on the 15 mg dose recorded a mean body-weight reduction of 20.9%, versus 3.1% on placebo[1]. 57% of that group lost a fifth or more of their body weight, and 91% lost at least 5%[1]
This is a frequent side effect, particularly when you first begin treatment or when your dosage is increased
doi: 10.4149/gpb_2018005 87
After being activated by insulin signaling, Akt inactivates AS160 (GTPase-activating protein [GAP] AKT substrate of 160 kDa, also known as TBC1D4), which activates small Rab GTPase protein switches that control vesicle trafficking [10]
Will doctors give B12 shots
Study populations and endpoints differ across these trials, and results vary from person to person
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