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New England Journal of Medicine .PMID 37366315DOI 10.1056/NEJMoa2301972Read source (2025)
Discussion While GLP-1 RAs are powerful anti-obesity medications (AOMs), they do raise some serious concerns most notably, up to 40% of the profound weight loss induced by these agents can be due to loss of lean mass 3,4,5 and prior studies have shown that a significant portion of this lean mass is muscle 33,34,35
Some of these compoundsparticularly berberine and fiberhave legitimate metabolic effects supported by research
But keep in mind that it may not lead to the same weight loss either
The body picks up what it needs
Kidney Impairment Use Hepaglide 1.7 mg Injection with caution in patients with kidney disease, as it can worsen kidney function or exacerbate dehydration-related issues, such as vomiting
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