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Comparative trials assessing GLP-1 monotherapy against dual and triple agonists in pediatric populations
Phase 3 trials demonstrated average weight loss of 15% when semaglutide was used specifically for weight management, compared to placebo
Short-acting GLP1s cause more nausea
They may support gut health for some people, but they havent been shown to replicate the appetite or weight-loss effects of GLP-1 medications
As Spreckleys (2026) research found, GLP1 medications are effective for weight loss, a lack of appropriate nutrition oversight has lead to significant lean body mass loss and widespread nutritional deficiencies
Cell 163 (5), 10791094
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