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These are the most common side effects of GLP-1s

A suggested mechanism involves prolonged GIPR agonism causing receptor degradation, reducing sustained GIP signalling and, when combined with GLP-1R agonism, causing increased weight loss ( The GLP-1R has itself several LoF variants including R380C, shown by two independent groups to have normal surface expression but reduced affinity for Exenatide (Wootten et al., 2016

Fidai, M., Alsaif, A., & Hwang, S

Timing can feel like an important decision when youre taking GLP-1 injections like Ozempic, Wegovy, or Mounjaro

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