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Mechanisms deciphered in these studies indicate that the interaction between serotonin and GLP-1 in the hindbrain increases proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, leading to induction of satiety signals and suppression of neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which in turn suppresses hunger

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Because these drugs essentially act as hormones (which, once metabolized, lose their efficacy), this drop in adherence may not bode well for maintaining the effects of these drugs in the long term

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The C-terminal half of TM6 exhibits relatively poor density, reflecting its intrinsic flexibility

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