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Researchers initially examined it in the context of obesity and metabolic-syndrome research models, exploring whether modulating NNMT alters markers of substrate utilisation and energy expenditure
Collectively, these results provide a novel foundation for future investigations
A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets
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