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Long-term efficacy, safety & duration: While GLP-1s have shown impressive short-term results, the long-term picture remains blurry
Tyna Moore on these incredible new weight-loss drugs and their application
Although no data from head-to-head trials comparing retatrutide to other currently approved obesity treatments exist, data from the phase 2 studies with retatrutide suggest that at higher doses, retatrutide could lead to greater WL compared to the most efficacious approved treatments for obesity and T2D such as tirzepatide 15 mg and semaglutide 2.4 mg (Fig
Obesity and insulin resistance are risk factors, along with genetics
Their mazdutide averaged 8.2 across 3 samples
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