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Freezing a reconstituted peptide solution is not recommended, because the freeze-thaw cycle can cause aggregation and denaturation that reduces potency

Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

Lenton KJ, San AT, Therriault H, Cantin AM, Payette H, Wagner JR