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Data availability All data generated and analyzed in this study are included in this article and its Supplementary Information files

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GLP-1 drugs found to boost testosterone in men with obesity or diabetes Key Takeaways: Anti-obesity medications significantly raised testosterone levels in men with obesity or type 2 diabetes

In light of the estimated 20 mM total intracellular Cys concentration ( 41 , 42 ) and the fact that most mammalian proteins have at least one Cys residue ( 43 ), the quantified ~0.1 to 1% persulfidation of the total protein pool in cells (1.52 0.55 g/mg total protein in HEK293 cells) and liver tissue (11.6 6.9 g/mg total protein in mice), respectively, correlates very well with the ~10 to 100 M small-molecule persulfide (mostly GSH persulfide) concentrations in A549 cells and mouse liver, respectively, that were measured by Ida et al

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