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Growth Hormone and Aging: New Findings
During bone resorption by osteoclasts, multiple growth factors and cytokines are acvitated and released from the bone matrix to recruit MSCs and induce differentiation into mature osteoblasts in coupling bone formation with resorption (5,20,29,31,32)
This is consistent with crypt hyperplasia and expansion of the transit-amplifying zone, both histologic hallmarks of inflammation
13,14 This reduction in MACE, which is not explained by improvements in glycaemia and nonglycaemic cardiovascular risk factors, remains to be fully elucidated but may reflect other effects of GLP-1 analogues such as their antioxidative and anti-inflammatory properties
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