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Kiel DW, Dodson EA, Artal R, Boehmer TK, Leet TL

Potential Benefits of a Weekly B12 Schedule It is important to be clear up front: these benefits apply mainly to people who are actually low in B12

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Ideal candidates typically include adults with type 2 diabetes who have inadequate glycaemic control (HbA1c above individualised target) despite treatment with metformin and/or other oral agents, particularly those with additional cardiovascular or renal risk factors

Additionally, their interactions with other medications add complexity to treatment plans, making them less appealing for extended use