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While not everyone will experience constipation while taking tirzepatide, it can occur in some cases

Persistent sulfur burps with diarrhea can sometimes indicate an underlying condition like gastrointestinal dysfunction that the medication is exacerbating rather than causing

Daniel Lee: This author declares that they have no conflict of interest

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The SURPASS-CVOT trial, where dulaglutide at the dose of 1.5 mg/week or at the highest tolerated dose, is the comparator, has a distinctive design from the other trials: the primary endpoint is the time to the first manifestation of any major adverse CV event (MACE), defined as myocardial infarction, stroke or CV death

Weeks 9-12: 1.0 mg once weekly