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Insurers weigh the short-term cost of GLP-1 therapies (up to ~$17K annually) against the long-term savings from reduced obesity-related complications
This combination addresses the primary concern with GLP-1 medications: significant lean tissue loss during aggressive caloric deficits
For someone managing type 2 diabetes, this means blood glucose levels creep upward
However, acarbose needs to be taken with every meal, is ineffective on monosaccharides, and may cause gastrointestinal side effects
While these initial changes can feel encouraging, lasting weight loss takes more time
PMID: 14737078
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